T8552

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T8552

Sigma

 

Trichostatin A

≥98% (HPLC), from Streptomyces sp.

Synonym:TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
CAS Number:58880-19-6
Empirical Formula (Hill Notation):C17H22N2O3
Molecular Weight:302.37
MDL number:MFCD03848392
PubChem Substance ID:24900542

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Description

Frequently Asked QuestionsLive Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol ActionsInhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.

Properties

biological source from Streptomyces sp.
assay≥98% (HPLC)
EQP levelPremium
solubilityethanol: soluble2 mg/mL
Gene InformationResearch your gene in Your Favorite Gene powered by Ingenuity
human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)
rat ... Hdac7a(84582)
mouse ... ENSMUSG00000061062(15181)
storage temp.−20°C

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard CodesXn
Risk Statements20/21/22-36/37/38-43
Safety Statements26-36
WGK Germany3
RTECSMI5215000

References

referenceYoshida, M., et al., Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays 17, 423-430, (1995) Abstract
 Minucci, S., et al., A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. Proc. Natl. Acad. Sci. U. S. A. 94, 11295-11300, (1997) Abstract
 Brehm, A., et al., Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391, 597-601, (1998) Abstract
 Sowa, R., et al., Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. Biochem. Biophys. Res. Commun. 241, 142-150, (1997) Abstract
 Medina, V., et al., Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. Cancer Res. 57, 3697-3707, (1997) Abstract
 Kim, M.S., et al., Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res. 63, 7291-7300, (2003) Abstract